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Why are these sprays concerning

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Nausea: Often reported during the first few weeks, nausea is one of the most common side effects

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In addition to heterogeneity, potential sources of bias must be considered, particularly in observational studies assessing treatment persistence and real-world effectiveness

The dose can be increased at 4-week intervals to 0.5 mg, 1 mg, 1.7 mg, or 2.4 mg per week as needed to sustain weight loss